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Blood, 1 September 2008, Vol. 112, No. 5, pp. 2092-2100. Prepublished online as a Blood First Edition Paper on June 3, 2008; DOI 10.1182/blood-2008-03-143677. This Article Full Text Full Text (PDF) All Versions of this Article: blood-2008-03-143677v1 112/5/2092    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Google Scholar Articles by Vasu, S. Articles by Bolan, C. D. PubMed PubMed Citation Articles by Vasu, S. Articles by Bolan, C. D. Related Collections Transfusion Medicine Transplantation Free Research Articles Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSFUSION MEDICINE Donor demographic and laboratory predictors of allogeneic peripheral blood stem cell mobilization in an ethnically diverse population Sumithira Vasu1, Susan F. Leitman1, John F. Tisdale2, Matthew M. Hsieh2, Richard W. Childs3, A. John Barrett3, Daniel H. Fowler4, Michael R. Bishop4, Elizabeth M. Kang5, Harry L. Malech5, Cynthia E. Dunbar3, Hanh M. Khuu1, Robert Wesley6, Yu Y. Yau1, and Charles D. Bolan3 1 Department of Transfusion Medicine, Warren Grant Magnuson Clinical Center; 2 Molecular Hematology Section, National Institute of Diabetes, Digestive and Kidney Diseases; 3 Hematology Branch, National Heart, Lung and Blood Institute; 4 Experimental Transplantation and Immunology Branch, National Cancer Institute; 5 Laboratory of Host Defenses, National Institute of Allergy, Immunology and Infectious Diseases; and 6 Biostatistics and Clinical Epidemiology Service, Clinical Center; National Institutes of Health, Bethesda, MD A reliable estimate of peripheral blood stem cell (PBSC) mobilization response to granulocyte colony-stimulating factor (G-CSF) may identify donors at risk for poor mobilization and help optimize transplantation approaches. We studied 639 allogeneic PBSC collections performed in 412 white, 75 black, 116 Hispanic, and 36 Asian/Pacific adult donors who were prescribed G-CSF dosed at either 10 or 16 µg/kg per day for 5 days followed by large-volume leukapheresis (LVL). Additional LVL (mean, 11 L) to collect lymphocytes for donor lymphocyte infusion (DLI) and other therapies was performed before G-CSF administration in 299 of these donors. Day 5 preapheresis blood CD34+ cell counts after mobilization were significantly lower in whites compared with blacks, Hispanics, and Asian/Pacific donors (79 vs 104, 94, and 101 cells/µL, P < .001). In addition, donors who underwent lymphapheresis before mobilization had higher CD34+ cell counts than donors who did not (94 vs 79 cells/µL, P < .001). In multivariate analysis, higher post–G-CSF CD34+ cell counts were most strongly associated with the total amount of G-CSF received, followed by the pre–G-CSF platelet count, pre–G-CSF mononuclear count, and performance of prior LVL for DLI collection. Age, white ethnicity, and female gender were associated with significantly lower post–G-CSF CD34+ cell counts. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

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